Heterogeneous Recoverability in Gene Expression —Post-Hypoxia Reoxygenation (GSE1041)
Representative gene expression trajectories following hypoxia–reoxygenation.
While many trajectories return toward baseline, a subset remains displaced at 24h, suggesting that recovery may not be uniformly accessible within a finite observation window.
A minimal analysis exploring whether gene expression recovery after hypoxia remains uniformly accessible across all trajectories.
While biological systems are often described as robust, this work examines whether recovery within finite time windows may be heterogeneous.
We introduce a simple observable: delta-recovery, which quantifies whether gene expression trajectories return toward baseline within a fixed observation window.
Results suggest that most genes return or remain near baseline, while a non-negligible subset remains displaced at 24h.
This pattern is consistent across thresholds and robust to replicate variability.
These observations are consistent with the possibility that some regions of state space may remain structurally present but become dynamically inaccessible within finite recovery timescales.
This analysis does not demonstrate inaccessibility directly, but provides an observable pattern consistent with time-constrained recoverability.
The framework is intentionally minimal, open, and designed for falsifiability.
DOI (Zenodo)
https://doi.org/10.5281/zenodo.19420941
View Code (GitHub)
https://github.com/jaimeojse-collab/heterogeneous-recoverability-gse1041
This work may be consistent with minimal dynamical models of recoverability boundaries.
